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ResearchIn-Press PreviewNephrology Open Access | 10.1172/JCI178392
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Yang, J. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Zhuang, H. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Li, J. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Nunez-Nescolarde, A. in: JCI | PubMed | Google Scholar |
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Luo, N. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Chen, H. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Li, A. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Qu, X. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Wang, Q. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Fan, J. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Bai, X. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Ye, Z. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Gu, B. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Meng, Y. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Zhang, X. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Wu, D. in: JCI | PubMed | Google Scholar |
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Sia, Y. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Jiang, X. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Chen, W. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Combes, A. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Nikolic-Paterson, D. in: JCI | PubMed | Google Scholar
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
4Department of Anatomy and Developmental Biology, Monash Biomedicine Discove, Monash University, Clayton, Australia
5The Second Clinical College, Guangdong Medical University, Dongguan, China
6Department of Nephrology, Monash Health and Monash University Department of Medicine, Clayton, Australia
7Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
8Department of Nephrology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangdong, China
9Department of Clinical Laboratory, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China
10Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
11School of Life Science, Tsinghua University, Beijing, China
12Department of Nephrology, Monash Health and Monash University Department of Medicine, Monash, Australia
Find articles by Yu, X. in: JCI | PubMed | Google Scholar
Published April 16, 2024 - More info
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregulation of a secreted micropeptide, C4orf48 (Cf48), in mouse diabetic nephropathy. Cf48 RNA and protein levels were upregulated in tubular epithelial cells in human and experimental CKD. Serum Cf48 levels were increased in human CKD and correlated with loss of kidney function, increasing CKD stage, and the degree of active interstitial fibrosis. Cf48 overexpression in mice accelerated renal fibrosis, while Cf48 gene deletion or knockdown by antisense oligonucleotides significantly reduced renal fibrosis in CKD models. In vitro, recombinant Cf48 (rCf48) enhanced TGF-β1-induced fibrotic responses in renal fibroblasts and epithelial cells independent of Smad3 phosphorylation. Cellular uptake of Cf48 and its pro-fibrotic response in fibroblasts operated via the transferrin receptor. RNA immunoprecipitation-sequencing identified Cf48 binding to mRNA of genes involved in the fibrotic response, including Serpine1, Acta2, Ccn2, and Col4a1. rCf48 binds to the 3′-untranslated region of Serpine1 and increases mRNA half-life. We identify the secreted Cf48 micropeptide as a potential enhancer of renal fibrosis which operates as an RNA-binding peptide to promote the production of extracellular matrix.
View Supplementary Table S1. Control (age-matched Nos3-/-) vs Nos3-/- DN gene annotation (Ribo-seq).
View Supplementary Table S4. Characteristics of CKD patients among groups.
View Supplementary Table S6. IP/MS identified Cf48 interacting proteins.
View Supplementary Table S9. RIP-seq analysis reveals IP and Input RNA read counts.
View Supplementary Table S10. RIP-seq analysis reveals Cf48 targets (RNAs).
View Supplementary Table S11. Gene Ontology analysis reveals Cf48 Cellular Components.
View Supplementary Table S12. Recombinant Fc-Flag-Cf48 protein sequence.
View Supplementary Table S13. cDNA primers used in real-time PCR measurements.
View Supplementary Table S14. Rat Tfrc and human TFRC siRNA and NC siRNA sequences