[HTML][HTML] Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis
DM Shih, YR Xia, XP Wang, E Miller… - Journal of Biological …, 2000 - ASBMB
Serum paraoxonase (PON1), present on high density lipoprotein, may inhibit low density
lipoprotein (LDL) oxidation and protect against atherosclerosis. We generated combined
PON1 knockout (KO)/apolipoprotein E (apoE) KO and apoE KO control mice to compare
atherogenesis and lipoprotein oxidation. Early lesions were examined in 3-month-old mice
fed a chow diet, and advanced lesions were examined in 6-month-old mice fed a high fat
diet. In both cases, the PON1 KO/apoE KO mice exhibited significantly more atherosclerosis …
lipoprotein (LDL) oxidation and protect against atherosclerosis. We generated combined
PON1 knockout (KO)/apolipoprotein E (apoE) KO and apoE KO control mice to compare
atherogenesis and lipoprotein oxidation. Early lesions were examined in 3-month-old mice
fed a chow diet, and advanced lesions were examined in 6-month-old mice fed a high fat
diet. In both cases, the PON1 KO/apoE KO mice exhibited significantly more atherosclerosis …
