[HTML][HTML] Osteopontin deficiency in rat vascular smooth muscle cells is associated with an inability to adhere to collagen and increased apoptosis
AS Weintraub, LM Schnapp, X Lin, MB Taubman - Laboratory investigation, 2000 - Elsevier
Osteopontin (OPN) is an extracellular matrix protein that has been implicated in vascular
smooth muscle cell (VSMC) adhesion. We have previously described the generation of OPN-
deficient VSMC that displayed altered adhesion to collagen. We have examined further the
causes and consequences of this altered adhesion. OPN-deficiency was associated with a
significant reduction in surface expression of α1 and β1 integrins (mean fluorescence
intensity α1: OPN-deficient 0.135±0.04 vs. control 0.313±0.05, p< 0.0001; β1: OPN-deficient …
smooth muscle cell (VSMC) adhesion. We have previously described the generation of OPN-
deficient VSMC that displayed altered adhesion to collagen. We have examined further the
causes and consequences of this altered adhesion. OPN-deficiency was associated with a
significant reduction in surface expression of α1 and β1 integrins (mean fluorescence
intensity α1: OPN-deficient 0.135±0.04 vs. control 0.313±0.05, p< 0.0001; β1: OPN-deficient …