We recently noted that immature rats failed to exhibit a normal uterine response to
exogenously administered estradiol as assessed by both biochemical (induction of gene
expression) and morphological (altered uterine and vaginal histology and size) end points.
An initial analysis suggested that this was due to a high degree of estrogenization from a
dietary source which was producing a near maximal uterotrophic response prior to hormone
treatment. Subsequent chemical analysis indicated that the feed in question contained high …