FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling
leads to diverse human pathologies including skeletal, olfactory, and metabolic disorders as
well as cancer. FGFs execute their pleiotropic biological actions by binding, dimerizing and
activating cell surface FGF receptors (FGFRs). Proper regulation of FGF–FGFR binding
specificity is essential for the regulation of FGF signaling and is achieved through primary …