Statin treatment inhibits oxidized lipoprotein-induced intracellular lipid accumulation (foam
cell formation) and reduces plasma levels of inflammatory markers such as interleukin-1β (IL-
1β). The aim of the present study was to determine if simvastatin affected lipid accumulation
in macrophages incubated with aggregated low density lipoproteins (AgLDL) and whether
simvastatin had a direct effect on cytokine secretion from macrophages. Simvastatin
treatment did not inhibit AgLDL-induced macrophage lipid accumulation, but significantly …