Hemolytic transfusion reactions (HTR) are systemic reactions provoked by immunologic red
blood cell (RBC) incompatibility. Clinical and experimental observations of such reactions
indicate that they proceed through phases of humoral immune reaction, activation of
phagocytes, productions of cytokine mediators, and wide-ranging cellular responses. HTR
have many features in common with the systemic inflammatory response syndrome (SIRS).
Knowledge of the pathophysiologic mechanisms in HTR suggest that newer biological …