A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates
HB Levy, G Baer, S Baron, CE Buckler… - Journal of Infectious …, 1975 - academic.oup.com
HB Levy, G Baer, S Baron, CE Buckler, CJ Gibbs, MJ Iadarola, WT London, J Rice
Journal of Infectious Diseases, 1975•academic.oup.comA complex of polyriboinosinic-polyribocytidylic acid (poly I· poly C) with poly-tlysine and
carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to
hydrolysis by primate serum as the parent poly I· poly C. It has a thermal denaturation
temperature about 40 C higher than that of poly I· poly C. The complex induces significant
levels of serum interferon in monkeys and chimpanzees under conditions in which poly I·
poly C itself induces no interferon.
carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to
hydrolysis by primate serum as the parent poly I· poly C. It has a thermal denaturation
temperature about 40 C higher than that of poly I· poly C. The complex induces significant
levels of serum interferon in monkeys and chimpanzees under conditions in which poly I·
poly C itself induces no interferon.
Abstract
A complex of polyriboinosinic-polyribocytidylic acid (poly I · poly C) with poly-tlysine and carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to hydrolysis by primate serum as the parent poly I · poly C. It has a thermal denaturation temperature about 40 C higher than that of poly I · poly C. The complex induces significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I · poly C itself induces no interferon.
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