[HTML][HTML] Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species
Thromboxane A 2 (TxA 2), the principle product of platelet COX-1-dependent arachidonic
acid metabolism, directs multiple pro-atherogenic processes via its receptor, TP. Oxidative
challenge offsets TP degradation, a key component in limiting TxA 2's actions. Following TP
activation, we observed cellular reactive oxygen species (ROS) generation coincident with
increased TP expression. We examined the link between TP-evoked ROS and TP
regulation. TP expression was augmented in TPα-transfected cells treated with a TxA 2 …
acid metabolism, directs multiple pro-atherogenic processes via its receptor, TP. Oxidative
challenge offsets TP degradation, a key component in limiting TxA 2's actions. Following TP
activation, we observed cellular reactive oxygen species (ROS) generation coincident with
increased TP expression. We examined the link between TP-evoked ROS and TP
regulation. TP expression was augmented in TPα-transfected cells treated with a TxA 2 …
