Hypoxia, gene expression, and metastasis
DA Chan, AJ Giaccia - Cancer and Metastasis Reviews, 2007 - Springer
DA Chan, AJ Giaccia
Cancer and Metastasis Reviews, 2007•SpringerHypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant
to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible
for increased invasion, aggressiveness, and metastasis of tumors. The augmented
metastatic potential due to hypoxia-mediated gene expression is discussed in this section.
Particular attention is given to recent studies of specific genes involved in the key steps of
metastasis, including extracellular matrix interactions, migration, and proliferation.
to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible
for increased invasion, aggressiveness, and metastasis of tumors. The augmented
metastatic potential due to hypoxia-mediated gene expression is discussed in this section.
Particular attention is given to recent studies of specific genes involved in the key steps of
metastasis, including extracellular matrix interactions, migration, and proliferation.
Abstract
Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.
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