Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age
DA Cottrell, EL Blakely, MA Johnson, PG Ince… - Neurobiology of …, 2001 - Elsevier
DA Cottrell, EL Blakely, MA Johnson, PG Ince, GM Borthwick, DM Turnbull
Neurobiology of aging, 2001•ElsevierThe chronological accumulation of mitochondrial dysfunction has been proposed as a
potential mechanism in the physiological processes of aging. Cytochrome c oxidase
deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of
a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders.
We show that there is an age-related increase in cytochrome c oxidase-deficient cells in
both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that …
potential mechanism in the physiological processes of aging. Cytochrome c oxidase
deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of
a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders.
We show that there is an age-related increase in cytochrome c oxidase-deficient cells in
both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that …
The chronological accumulation of mitochondrial dysfunction has been proposed as a potential mechanism in the physiological processes of aging. Cytochrome c oxidase deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders. We show that there is an age-related increase in cytochrome c oxidase-deficient cells in both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that these cells contribute to the cell death and dysfunction in CNS aging.
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