Autophagy is required for extension of yeast chronological life span by rapamycin
AL Alvers, MS Wood, D Hu, AC Kaywell, WA Dunn, Jr… - Autophagy, 2009 - Taylor & Francis
AL Alvers, MS Wood, D Hu, AC Kaywell, WA Dunn, Jr, JP Aris
Autophagy, 2009•Taylor & FrancisRapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes,
including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin
extend yeast chronological life span (CLS). We have recently shown that autophagy is
required for chronological longevity in yeast, which is attributable in part to a role for
autophagy in amino acid homeostasis. We report herein that low concentrations of
rapamycin stimulate macroautophagy during chronological aging and extend CLS.
including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin
extend yeast chronological life span (CLS). We have recently shown that autophagy is
required for chronological longevity in yeast, which is attributable in part to a role for
autophagy in amino acid homeostasis. We report herein that low concentrations of
rapamycin stimulate macroautophagy during chronological aging and extend CLS.
Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.
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