Transplanting the enteric nervous system: a step closer to treatment for aganglionosis
MD Gershon - Gut, 2007 - gut.bmj.com
MD Gershon
Gut, 2007•gut.bmj.comOne might think that Hirschsprung's disease (congenital megacolon) should be passé as a
medical problem. After all, many genes, including RET, GDNF, NRTN, EDNRB, EDN3,
ECE1, PHOX2b, SOX10, PAX3 and SMADIP1 (SIP1, ZBFX1B), 1–7 have successfully been
linked to its pathogenesis. Knowledge of the actions and interactions of these genes and
their products has enabled the processes by which the bowel is colonised to be, if not
completely understood, at least comprehended in
medical problem. After all, many genes, including RET, GDNF, NRTN, EDNRB, EDN3,
ECE1, PHOX2b, SOX10, PAX3 and SMADIP1 (SIP1, ZBFX1B), 1–7 have successfully been
linked to its pathogenesis. Knowledge of the actions and interactions of these genes and
their products has enabled the processes by which the bowel is colonised to be, if not
completely understood, at least comprehended in
One might think that Hirschsprung’s disease (congenital megacolon) should be passé as a medical problem. After all, many genes, including RET, GDNF, NRTN, EDNRB, EDN3, ECE1, PHOX2b, SOX10, PAX3 and SMADIP1 (SIP1, ZBFX1B), 1–7 have successfully been linked to its pathogenesis. Knowledge of the actions and interactions of these genes and their products has enabled the processes by which the bowel is colonised to be, if not completely understood, at least comprehended in
gut.bmj.com
