Exercise and insulin: Convergence or divergence at AS160 and TBC1D1?
Rev., Vol. 37, No. 4, pp. 188Y195, 2009. Akt substrate of 160 kDa (called AS160 or TBC1D4)
and TBC1D1, Rab GTPaseYactivating proteins that regulate glucose transport, become
phosphorylated with exercise or insulin stimulation. Evidence suggests that this
convergence may prove to be imperfect, and each stimulus will produce a unique
phosphosignature, providing a plausible mechanism for their apparently unique and
overlapping roles in exercise-and insulin-stimulated glucose transport.
and TBC1D1, Rab GTPaseYactivating proteins that regulate glucose transport, become
phosphorylated with exercise or insulin stimulation. Evidence suggests that this
convergence may prove to be imperfect, and each stimulus will produce a unique
phosphosignature, providing a plausible mechanism for their apparently unique and
overlapping roles in exercise-and insulin-stimulated glucose transport.
Rev., Vol. 37, No. 4, pp. 188Y195, 2009. Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPaseYactivating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise-and insulin-stimulated glucose transport.
Lippincott Williams & Wilkins