Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor
CL Faingold, S Tupal, M Randall - Epilepsy & Behavior, 2011 - Elsevier
DBA/1 mice are a chronically susceptible model of sudden unexpected death in epilepsy
(SUDEP) that exhibit chronic audiogenic generalized convulsive seizures (GCSs), leading to
death from respiratory arrest (RA) if not resuscitated. Serotonin (5-HT) normally enhances
respiration in response to elevated CO2 levels, which occur during GCSs in humans.
Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, increase 5-HT
availability. We examined whether fluoxetine can block GCS-induced sudden death in …
(SUDEP) that exhibit chronic audiogenic generalized convulsive seizures (GCSs), leading to
death from respiratory arrest (RA) if not resuscitated. Serotonin (5-HT) normally enhances
respiration in response to elevated CO2 levels, which occur during GCSs in humans.
Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, increase 5-HT
availability. We examined whether fluoxetine can block GCS-induced sudden death in …