T lymphocyte–specific activation of Nrf2 protects from AKI
S Noel, MN Martina, S Bandapalle… - Journal of the …, 2015 - journals.lww.com
T lymphocytes are established mediators of ischemia reperfusion (IR)–induced AKI, but
traditional immune principles do not explain their mechanism of early action in the absence
of alloantigen. Nrf2 is a transcription factor that is crucial for cytoprotective gene expression
and is generally thought to have a key role in dampening IR-induced AKI through protective
effects on epithelial cells. We proposed an alternative hypothesis that augmentation of Nrf2
in T cells is essential to mitigate oxidative stress during IR-induced AKI. We therefore …
traditional immune principles do not explain their mechanism of early action in the absence
of alloantigen. Nrf2 is a transcription factor that is crucial for cytoprotective gene expression
and is generally thought to have a key role in dampening IR-induced AKI through protective
effects on epithelial cells. We proposed an alternative hypothesis that augmentation of Nrf2
in T cells is essential to mitigate oxidative stress during IR-induced AKI. We therefore …
