Quantitative analysis of monoclonal immunoglobulins in serum of patients with amyotrophic lateral sclerosis
F Duarte, S Binet, L Lacomblez, P Bouche… - Journal of the …, 1991 - Elsevier
In a prospective study, we analysed the presence of monoclonal immunoglobulin (moIg) in
the serum from 30 patients with amyotrophic lateral sclerosis (ALS) and 30 matched controls
using a sensitive Western blot technique. The incidence of serum moIg was 60% in the ALS
group and 13.3% in the control group. Most ALS sera contained 2 or 3 monoclonal
components. They were IgG (72.7%) and IgM (27.3%). These results corroborate the
concept of a probable association between ALS and serum moIg.
the serum from 30 patients with amyotrophic lateral sclerosis (ALS) and 30 matched controls
using a sensitive Western blot technique. The incidence of serum moIg was 60% in the ALS
group and 13.3% in the control group. Most ALS sera contained 2 or 3 monoclonal
components. They were IgG (72.7%) and IgM (27.3%). These results corroborate the
concept of a probable association between ALS and serum moIg.