[HTML][HTML] Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1
Z Olah, L Karai, MJ Iadarola - Journal of Biological Chemistry, 2001 - ASBMB
The vanilloid receptor type 1 (VR1) is a heat-activated ionophore preferentially expressed in
nociceptive neurons of trigeminal and dorsal root ganglia (DRG). VR1, which binds and is
activated by capsaicin and other vanilloid compounds, was noted to interact with the
endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic
acid in a pH-dependent manner. At pH≤ 6.5 ANA induced 45 Ca 2+ uptake either in primary
cultures of DRG neurons or cells ectopically expressing C-terminally tagged recombinant …
nociceptive neurons of trigeminal and dorsal root ganglia (DRG). VR1, which binds and is
activated by capsaicin and other vanilloid compounds, was noted to interact with the
endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic
acid in a pH-dependent manner. At pH≤ 6.5 ANA induced 45 Ca 2+ uptake either in primary
cultures of DRG neurons or cells ectopically expressing C-terminally tagged recombinant …
