Chemokine receptors constitute an attractive family of drug targets in the frame of
inflammatory diseases. However, targeting specific chemokine receptors may be
complicated by their ability to form dimers or higher order oligomers. Using a combination of
luminescence complementation and bioluminescence resonance energy transfer assays,
we demonstrate for the first time the existence of hetero-oligomeric complexes composed of
at least three chemokine receptors (CCR2, CCR5, and CXCR4). We show in T cells and …