Role of heat shock proteins in stem cell behavior

GC Fan - Progress in molecular biology and translational …, 2012 - Elsevier
Stress response is well appreciated to induce the expression of heat shock proteins (Hsps)
in the cell. Numerous studies have demonstrated that Hsps function as molecular
chaperones in the stabilization of intracellular proteins, repairing damaged proteins, and
assisting in protein translocation. Various kinds of stem cells (embryonic stem cells, adult
stem cells, or induced pluripotent stem cells) have to maintain their stemness and, under
certain circumstances, undergo stress. Therefore, Hsps should have an important influence …