[HTML][HTML] Role of mTORC1–S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia
J Ghosh, R Kapur - Experimental hematology, 2017 - Elsevier
Highlights•The mechanistic target of rapamycin complex 1 (mTORC1)–p70 ribosomal
protein kinase 1 (S6K1) pathway is dysregulated in acute myeloid leukemia.•mTORC1 and
S6K1 regulate the function of leukemia stem cells.•mTORC1 and S6K1 are also critical
regulators of hematopoietic stem cell function.•The generation of mTORC1 inhibitors such as
RapaLink-1 could be a useful therapeutic tool against rapamycin-resistant leukemic
cells.Dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1)–p70 …
protein kinase 1 (S6K1) pathway is dysregulated in acute myeloid leukemia.•mTORC1 and
S6K1 regulate the function of leukemia stem cells.•mTORC1 and S6K1 are also critical
regulators of hematopoietic stem cell function.•The generation of mTORC1 inhibitors such as
RapaLink-1 could be a useful therapeutic tool against rapamycin-resistant leukemic
cells.Dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1)–p70 …