Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air
Hematopoietic cell transplantation (HCT) is a treatment for malignant and non-malignant
disorders. However, sometimes the numbers of donor hematopoietic stem cells (HSC) are
limiting, which can compromise the success of HCT. We recently published that collection
and processing of mouse bone marrow (BM) and human cord blood cells in a hypoxic
atmosphere of 3% O 2 or in ambient air (~ 21% O 2) in the presence of cyclosporine A yields
increased numbers of HSC. We now show that collection and processing of mouse BM cells …
disorders. However, sometimes the numbers of donor hematopoietic stem cells (HSC) are
limiting, which can compromise the success of HCT. We recently published that collection
and processing of mouse bone marrow (BM) and human cord blood cells in a hypoxic
atmosphere of 3% O 2 or in ambient air (~ 21% O 2) in the presence of cyclosporine A yields
increased numbers of HSC. We now show that collection and processing of mouse BM cells …
