[HTML][HTML] Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
M Tanno, A Kuno, T Yano, T Miura, S Hisahara… - Journal of Biological …, 2010 - ASBMB
Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD+-dependent
histone/protein deacetylase, promotes cell survival under oxidative stress when it is
expressed in the nucleus. However, adult cardiomyocytes predominantly express SIRT1 in
the cytoplasm, and its function has not been elucidated. The purpose of this study was to
investigate the functional role of SIRT1 in the heart and the potential use of SIRT1 in therapy
for heart failure. We investigated the subcellular localization of SIRT1 in cardiomyocytes and …
histone/protein deacetylase, promotes cell survival under oxidative stress when it is
expressed in the nucleus. However, adult cardiomyocytes predominantly express SIRT1 in
the cytoplasm, and its function has not been elucidated. The purpose of this study was to
investigate the functional role of SIRT1 in the heart and the potential use of SIRT1 in therapy
for heart failure. We investigated the subcellular localization of SIRT1 in cardiomyocytes and …