[HTML][HTML] Prolyl isomerase Pin1-mediated conformational change and subnuclear focal accumulation of Runx2 are crucial for fibroblast growth factor 2 (FGF2)-induced …
WJ Yoon, YD Cho, WJ Kim, HS Bae, R Islam… - Journal of Biological …, 2014 - ASBMB
Fibroblast growth factor 2 (FGF2) signaling plays a pivotal role in bone growth/differentiation
through the activation of osteogenic master transcription factor Runx2, which is mediated by
the ERK/MAPK-dependent phosphorylation and the p300-dependent acetylation of Runx2.
In this study, we found that Pin1-dependent isomerization of Runx2 is the critical step for
FGF2-induced Runx2 transactivation function. We identified four serine or threonine
residues in the C-terminal domain of Runx2 that are responsible for Pin1 binding and …
through the activation of osteogenic master transcription factor Runx2, which is mediated by
the ERK/MAPK-dependent phosphorylation and the p300-dependent acetylation of Runx2.
In this study, we found that Pin1-dependent isomerization of Runx2 is the critical step for
FGF2-induced Runx2 transactivation function. We identified four serine or threonine
residues in the C-terminal domain of Runx2 that are responsible for Pin1 binding and …
