S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice
W Zhang, W Zhang, Z Li, J Hao, Z Zhang, L Liu… - Pharmacology …, 2012 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
clinical cognitive decline and pathological deposition of amyloid-beta protein (Aβ) in the
brain. So far, there has been no causative therapy for this devastating disease. S14G-
Humanin (HNG), a synthetic derivative of Humanin (HN), has been shown to have strong
neuroprotective ability against AD-related insults in vitro and prevent cognitive impairments
in Aβ-infused animal models. In addition, a recent study has reported a beneficial effect of …
clinical cognitive decline and pathological deposition of amyloid-beta protein (Aβ) in the
brain. So far, there has been no causative therapy for this devastating disease. S14G-
Humanin (HNG), a synthetic derivative of Humanin (HN), has been shown to have strong
neuroprotective ability against AD-related insults in vitro and prevent cognitive impairments
in Aβ-infused animal models. In addition, a recent study has reported a beneficial effect of …
