Increasing hypothalamic nucleobindin 2 levels and decreasing hypothalamic inflammation in obese male mice via diet and exercise alleviate obesity-associated …
D Chen, S Cao, B Chang, T Ma, H Gao, Y Tong, T Li… - Neuropeptides, 2019 - Elsevier
To explore the role of nesfatin-1 in regulating male reproductive function during energy
balance variation, we employed an obese mouse model which was first induced by a high-
fat diet (HFD) and followed by interventions of a normal diet (ND) and/or moderate exercise,
and then serum reproductive hormones of male mice, hypothalamic nucleobindin 2
(NUCB2)/nesfatin-1, inflammatory factors, and gonadotropin-releasing hormone (GnRH)
levels were tested. Our findings showed that both serum nesfatin-1, follicle-stimulating …
balance variation, we employed an obese mouse model which was first induced by a high-
fat diet (HFD) and followed by interventions of a normal diet (ND) and/or moderate exercise,
and then serum reproductive hormones of male mice, hypothalamic nucleobindin 2
(NUCB2)/nesfatin-1, inflammatory factors, and gonadotropin-releasing hormone (GnRH)
levels were tested. Our findings showed that both serum nesfatin-1, follicle-stimulating …
