One of the earliest cellular responses to DNA double strand breaks (DSBs) is the
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the
level of γH2AX above baseline, measured at a given time-point beyond which DNA DSBs
are normally expected to be repaired (usually persist for days to months). This review
summarizes the concept of persistent γH2AX in the context of exogenous source induced
DNA DSBs (eg ionizing radiation (IR), chemotherapeutic drugs, genotoxic agents), and …