Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax
P Blombery, ER Thompson, T Nguyen… - Blood, The Journal …, 2020 - ashpublications.org
P Blombery, ER Thompson, T Nguyen, RW Birkinshaw, J Gong, X Chen, M McBean…
Blood, The Journal of the American Society of Hematology, 2020•ashpublications.orgThe BCL2 inhibitor venetoclax has complete response rates of up to 50% in chronic
lymphocytic leukemia patients, but secondary resistance reflecting acquired mutations in
BCL2 can lead to treatment failure. Blombery et al report that an unexpectedly large number
of patients carry multiple BCL2 mutations with subclonal variation in their occurrence.
lymphocytic leukemia patients, but secondary resistance reflecting acquired mutations in
BCL2 can lead to treatment failure. Blombery et al report that an unexpectedly large number
of patients carry multiple BCL2 mutations with subclonal variation in their occurrence.
The BCL2 inhibitor venetoclax has complete response rates of up to 50% in chronic lymphocytic leukemia patients, but secondary resistance reflecting acquired mutations in BCL2 can lead to treatment failure. Blombery et al report that an unexpectedly large number of patients carry multiple BCL2 mutations with subclonal variation in their occurrence.
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