Increased circulating procoagulant activity and thrombin generation in patients with myeloproliferative neoplasms
J Duchemin, V Ugo, JC Ianotto, L Lecucq, B Mercier… - Thrombosis research, 2010 - Elsevier
Microparticles (MPs) are membrane fragments ranging in size from 0.1 to 1μm, and are
considered as biomarkers reflecting prothrombotic state in many clinical diseases. The
clinical course of myeloproliferative neoplasms (MPN) being frequently complicated by
thrombotic events, we determined the MPs activity, ie circulating procoagulant activity (CPA),
in polycythemia vera (PV) and essential thrombocythemia (ET) patients. To evaluate the
influence of MPs on the coagulation, a thrombin generation test was realized in the absence …
considered as biomarkers reflecting prothrombotic state in many clinical diseases. The
clinical course of myeloproliferative neoplasms (MPN) being frequently complicated by
thrombotic events, we determined the MPs activity, ie circulating procoagulant activity (CPA),
in polycythemia vera (PV) and essential thrombocythemia (ET) patients. To evaluate the
influence of MPs on the coagulation, a thrombin generation test was realized in the absence …