Molecular cytogenetic profiling of complex karyotypes in primary myelodysplastic syndromes and acute myeloid leukemia
D Trost, B Hildebrandt, M Beier, N Müller… - Cancer genetics and …, 2006 - Elsevier
Complex chromosomal aberrations are present in≤ 30% of patients with primary
myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) and are associated with
a poor prognosis. Specific alterations in complex karyotypes are difficult to define by
conventional cytogenetics alone. To obtain a more comprehensive view of the recurrent
aberrations, we performed spectral karyotyping (SKY) and fluorescence in situ hybridization
(FISH) with selected probes on bone marrow samples from 17 patients with primary MDS …
myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) and are associated with
a poor prognosis. Specific alterations in complex karyotypes are difficult to define by
conventional cytogenetics alone. To obtain a more comprehensive view of the recurrent
aberrations, we performed spectral karyotyping (SKY) and fluorescence in situ hybridization
(FISH) with selected probes on bone marrow samples from 17 patients with primary MDS …