Maturing of the nuclear receptor family
Mitchell A. Lazar
Mitchell A. Lazar
Published April 3, 2017
Citation Information: J Clin Invest. 2017;127(4):1123-1125. https://doi.org/10.1172/JCI92949.
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Category: Review Series

Maturing of the nuclear receptor family

Abstract

Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the JCI includes a series of Review articles focused on specific NRs and their wide range of biological functions. Here I reflect on the past, present, and potential future highlights of research on the NR superfamily.

Authors

Mitchell A. Lazar

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Figure 1

Progress in the NR field.

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Progress in the NR field. Important discoveries are noted relevant to on...
Important discoveries are noted relevant to one another in terms of time as well as whether the discovery was a general feature of NRs (blue) or specific to only one or a few NRs (pink). LBD, ligand-binding domain; DBD, DNA-binding domain.